• SUTAPA SOM CHAUDHURY

      Articles written in Journal of Biosciences

    • COVID-19 and central nervous system interplay: A big picture beyond clinical manifestation

      SUTAPA SOM CHAUDHURY KOEL SINHA RABINDRANATH MAJUMDER ATANU BISWAS CHITRANGADA DAS MUKHOPADHYAY

      More Details Abstract Fulltext PDF

      The coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been declared a pandemic. Global research updates confirm that the infected patients manifest a range ofclinical symptoms and sometimes remain entirely asymptomatic, posing a greater threat to the people comingin contact. Despite several case reports coming up every day, our knowledge about the neurotropic mechanismof the SARS-CoV-2, immunological responses, and the mode of disease progression and mechanism of crosstalkbetween the central nervous system (CNS), heart, lungs, and other major organs is not complete. Report ofanosmia, ataxia, dysgeusia, and altered psychological status of the infected COVID-19 patients offers someclue to the possible route of viral entry and multiplication. In this review, we have critically assessed theinvolvement of CNS dysregulation in COVID-19 patients. The probable mechanism of immunologicalresponses, the impairment of the coagulation pathway, the onset of cytokine storm, its interplay with the HPAaxis, and hypoxia are discussed in detail here. Based on the latest research findings and some case reports ofhospitalized COVID-19 patients, it is evident that the CNS involvement in disease progression is alarming.Accurate and timely detection of viral load in CNS is necessary to allow prompt and effective treatmentmodalities.

      Possible entry sites of SARS-CoV-2 to the central nervous system of human being and the downstream manifestations.

  • Journal of Biosciences | News

    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

© 2021-2022 Indian Academy of Sciences, Bengaluru.