• SHWETA TYAGI

      Articles written in Journal of Biosciences

    • Diverse roles of WDR5-RbBP5-ASH2L-DPY30 (WRAD) complex in the functions of the SET1 histone methyltransferase family

      AAMIR ALI SHWETA TYAGI

      More Details Abstract Fulltext PDF

      WD repeat containing protein 5 (WDR5), Retinoblastoma Binding Protein 5 (RbBP5), Absent-Small-Homeotic-2-Like protein (ASH2L), and Dumpy-30 (Dpy30) have been reported to be the integral and shared components of all theSET1 family of histone 3 lysine 4 histone methyltransferase (HMT) complexes. Collectively called the WRADcomplex, these proteins are pivotal to the HMT activity of the SET1 complexes. Recent reports highlight the novelnon-canonical functions of WRAD in cellular processes other than its well-studied role in histone methylation andgene expression. In this review, we examine the diversity in emerging transcription-independent functions of WRAD.

  • Journal of Biosciences | News

© 2017-2019 Indian Academy of Sciences, Bengaluru.