Articles written in Journal of Biosciences

    • Somatic PI3K activity regulates transition to the spermatocyte stages in Drosophila testis


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      Spermatogenesis, involving multiple transit amplification divisions and meiosis, occurs within an enclosure formed bytwo somatic cells. As the cohort of germline cells divide and grow, the surface areas of the somatic cells expandmaintaining a tight encapsulation throughout the developmental period. Correlation between the somatic cell growthand germline development is unclear. Here, we report standardization of a quantitative assay developed for estimatingthe somatic roles of target molecules on germline division and differentiation in Drosophila testis. Using the assay, westudied the somatic roles of phosphatidylinositol-3-kinase (PI3K). It revealed that the expression of PI3KDN is likelyto facilitate the early germline development at all stages, and an increase in the somatic PI3K activity during the earlystages delays the transition to spermatocyte stage. Together, these results suggest that somatic cell growth plays animportant role in regulating the rate of germline development.

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