Articles written in Journal of Biosciences
Volume 1 Issue 2 June 1979 pp 159-168
An enzyme catalysing the hydrolysis of
Volume 1 Issue 4 December 1979 pp 385-392
The results presented in this paper show that lysis of human erythrocytes by linoleic acid is not caused by peroxidation of the fatty acid. Peroxidase, superoxide dismutase and scavengers of O2− and OH had no effect on the lysis while catalase showed only marginal inhibition suggesting that O2−, OH, O2− and H2O2 do not play any direct role in hemolysis by linoleic acid. Generators of H2O2 inhibited the lysis completely and methemoglobin cells were more resistant to hemolysis by linoleic acid. The fatty acid did neither bind to nor fomed complex with red cell ghosts. Membrane oxidation of sulphydryl groups was also not involved in the lysis. Β-Carotene, retinol and bile salts enhanced the lysis, while, cholesterol but not cholesterol acetate, inhibited it. Taurocholate-pretreated cells were more susceptible to linoleic acid lysis. These observations suggested-that lysis by linoleic acid may be due to its detergent property.
Volume 6 Issue 3 September 1984 pp 325-330
A study on the effect of retinol