Articles written in Journal of Biosciences
Volume 10 Issue 2 June 1986 pp 227-234
Effect of mandur bhasma on lipolytic activities of liver, kidney and adipose tissue of albino rat during CCl4 induced hepatic injury
Pratibha Devarshi Aruna Kanase Ravindra Kanase Sadashiv Mane Subhash Patil A T Varute
‘Mandur bhasma’, an ayurvedic preparation of iron is used in traditional medicine against hepatitis. In the present study the hepatoprotective property of this drug was tested in albino rats during CC14 induced hepatic injury. The effect of mandur bhasma on the activities of the lipolytic enzymes of rat liver, kidney and adipose tissue were studied during hepatitis induced by CCl4. The activities of acid lipase, alkaline lipase, lipoprotein lipase and hormone sensitive lipase exhibited significant alterations during CCl4 induced hepatic injury, indicating a role for these enzymes in the mobilization of fat from adipose tissue and accumulation of fat in liver and kidney. Simultaneous treatment with mandur bhasma prevented the paraffin mediated and CC14 mediated changes in the enzyme activities. These results suggest the hepatoprotective role of mandur bhasma during CCl4 induced hepatic injury.
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