Articles written in Journal of Biosciences
Volume 29 Issue 1 March 2004 pp 105-110 Clipboard
The determinants of offspring size and number in the tropical oviparous multi-clutched lizard,
Volume 32 Issue 6 September 2007 pp 1213-1220 Review
During the past decade, maternally derived steroid hormones in the egg yolk of oviparous vertebrates have been the focus of attention for their possible role in sex determination and hence, information on the consequences of maternal egg yolk steroids on sex determination has accumulated rapidly in reptiles and birds. Until recently, the observations were dominated by the idea that yolk steroids of maternal origin play an important role in sex determination of oviparous vertebrates. However, more recent studies have cast significant doubt on the above conclusion. These studies suggest instead that steroids may be present in the yolk simply as the byproduct of passive uptake during yolk formation or observed correlations might reflect embryonically produced rather than maternally derived steroids. Thus, the objective of the present review is
to provide an overview of such paradoxical observations on the role of maternal yolk steroids in sex determination of reptiles,
to identify and provide brief explanations for the observed paradoxical results, and
to provide some future research directions.
Volume 37 Issue 6 December 2012 pp 979-987 Articles
Specimens of the anterior lens capsule with an attached monolayer of lens epithelial cells (LECs) were obtained from patients (𝑛=52) undergoing cataract surgery. Specimens were divided into three groups based on the type of cataract: nuclear cataract, cortical cataract and posterior subcapsular cataract (PSC). Clear lenses (𝑛=11) obtained from donor eyes were used as controls. Expression was studied by immunofluorescence, real-time PCR and Western blot. Statistical analysis was done using the student’s 𝑡-test. Immunofluorescence results showed punctate localization of Cx43 at the cell boundaries in controls, nuclear cataract and PSC groups. In the cortical cataract group, cytoplasmic pools of Cx43 without any localization at the cell boundaries were observed. Real-time PCR results showed significant up-regulation of Cx43 in nuclear and cortical cataract groups. Western blot results revealed significant increase in protein levels of Cx43 and significant decrease of ZO-1 in all three cataract groups. Protein levels of alpha-catenin were decreased significantly in nuclear and cortical cataract group. There was no significant change in expression of beta-catenin in the cataractous groups. Our findings suggest that ZO-1 and alpha-catenin are important for gap junctions containing Cx43 in the LECs. Alterations in cell junction proteins may play a role during formation of different types of cataract.
Volume 46, 2020
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