R R GANGAKHEDKAR
Articles written in Journal of Biosciences
Volume 42 Issue 3 September 2017 pp 481-490 Article
The pathogenesis of HIV-associated neurocognitive disorder (HAND) is modulated by host genetic susceptibility factorssuch as Matrix metalloproteinases (MMPs). Promoter polymorphism of MMP-1 and MMP-3 may modify the expression ofthe gene. Hence, we evaluated the association of MMP-1-16072G/1G and MMP-3-1612 5A/6A polymorphisms withdevelopment of HAND and the modulation of pathogenesis of HAND. We enrolled a total of 180 individuals, 50 HIVinfectedindividuals with HAND, 130 without HAND, and 150 healthy controls. Polymorphism of MMP-1 and MMP-3were genotyped by PCR-RFLP. MMP-1-1607 2G1G, -16071G/2G-1G/1G genotypes and -1607 1G allele were associatedwith the development of HAND (OR = 1.64, P = 0.05; OR = 1.45, P = 0.04; OR = 1.69, P = 0.05). MMP-1-16071G1G, MMP-3-16125A5A genotypes increased the risk for the development of HAND (OR = 1.78, P = 0.25;OR = 2.39, P = 0.13). MMP-3-1612 5A5A, -1612 6A/5A-5A/5A genotypes and -1612 5A allele were associated with thereduced risk of HAND (OR = 0.40, P = 0.05; OR = 0.53, P = 0.04; OR = 0.40, P = 0.01). Haplotype 5A1G increasedthe risk of development of HAND (OR = 1.93, P = 0.05). As observed in advanced HIV disease stage, MMP-1-16071G1G genotype enhance the risk for advancement of HIV disease (OR = 1.69, P = 0.89). MMP-3-1612 6A5A genotypeshowed higher risk for development of HAND in alcohol users (0R = 1.65, P = 0.44). MMP-1 genotype may have aninfluence on development of HAND whereas MMP3-1612 5A5A genotype may reduce risk for pathogenesis of HAND.
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