R P Ojha
Articles written in Journal of Biosciences
Volume 16 Issue 1-2 June 1991 pp 29-42
The nucleoside antibiotic, 3′-azido-3′-deoxythymidine, or simply, azidothymidine has shown great promise in inhibiting the human immuno deficiency virus and in reducing mortality among AIDS patients. Conformational properties of azidothymidine have been investigated by quantum-mechanical PCILO method and compared with those of the parent nucleoside, thymidine. The results indicate great similarity between them and this similarity is remarkably striking in the situations that prevail in aqueous solution. This result has important biological significance in explaining the drug action of azidothymidine.
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