Articles written in Journal of Biosciences

    • Molecular analysis of the human faecal archaea in a southern Indian population


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      Archaea are an important constituent of the human gut microbiota, but there is no information on human gut archaea inan Indian population. In this study, faecal samples were obtained from different age groups (neonatal babies, preschoolchildren, school-going children, adolescents, adults and elderly) of a southern Indian population, and from atribal population also resident in southern India). 16S rRNA gene sequences specific to Archaea were amplified frompooled faecal DNA in each group, sequenced, and aligned against the NCBI database. Of the 806 adequate sequencesin the study, most aligned with 22 known sequences. There were 9 novel sequences in the present study. All sequenceswere deposited in the GenBank nucleotide sequence database with the following accession numbers: KF607113 -KF607918. Methanobrevibacter was the most prevalent genus among all the age groups accounting for 98% inneonates, 96% in post-weaning, and 100% each in preschool, school and adult population. In the elderly, Methanobrevibacteraccounted for 96% and in tribal adults, 99% of the clones belonged to Methanobrevibacter genus. Othergenera detected included Caldisphaera, Halobaculum, Methanosphaeraand Thermogymnomonas. Methanobrevibactersmithii predominated in all age groups, accounting for 749 (92.9%) of the 806 sequences. Archaea can befound in the faeces of southern Indian residents immediately after birth. Methanobrevibacter smithii was the dominantfaecal archeon in all age groups, with other genera being found at the extremes of age.

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