Articles written in Journal of Biosciences
Volume 46 All articles Published: 27 May 2021 Article ID 0047 Review
The coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been declared a pandemic. Global research updates confirm that the infected patients manifest a range ofclinical symptoms and sometimes remain entirely asymptomatic, posing a greater threat to the people comingin contact. Despite several case reports coming up every day, our knowledge about the neurotropic mechanismof the SARS-CoV-2, immunological responses, and the mode of disease progression and mechanism of crosstalkbetween the central nervous system (CNS), heart, lungs, and other major organs is not complete. Report ofanosmia, ataxia, dysgeusia, and altered psychological status of the infected COVID-19 patients offers someclue to the possible route of viral entry and multiplication. In this review, we have critically assessed theinvolvement of CNS dysregulation in COVID-19 patients. The probable mechanism of immunologicalresponses, the impairment of the coagulation pathway, the onset of cytokine storm, its interplay with the HPAaxis, and hypoxia are discussed in detail here. Based on the latest research findings and some case reports ofhospitalized COVID-19 patients, it is evident that the CNS involvement in disease progression is alarming.Accurate and timely detection of viral load in CNS is necessary to allow prompt and effective treatmentmodalities.
Possible entry sites of SARS-CoV-2 to the central nervous system of human being and the downstream manifestations.
Volume 46, 2021
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