Articles written in Journal of Biosciences

    • Thymoquinone induces cytotoxicity and reprogramming of EMT in gastric cancer cells by targeting PI3K/Akt/mTOR pathway


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      Gastric cancer is one of the lethal causes of cancer-related deaths worldwide. The incidence and mortality rates of thisdisease is comparatively higher in China. In the current study, we evaluated the anticancer effects of Thymoquinone (TQ)against gastric cancer cells (MGC80-3 and SGC-7901) and normal noncancerous GES-1 cells and attempted to investigatethe underlying mechanism. Our results indicated that TQ exhibited significant growth inhibitory effects on gastric cancercells (MGC80-3 and SGC-7901). However, lower cytotoxicity was observed against normal GES-1 cells. Moreover, TQcould inhibit the colony formation potential of MGC80-3 and SGC-7901 cells in a dose-dependent manner. TQ alsoinhibited cell migration ability of the gastric cancer cells and down-regulated the expression of the mesenchymal genes suchas N-cadherin, Vimentin, and TWIST. However, the epithelial markers such as E-cadherin and cytokeratin-19 were distinctlyup-regulated in TQ-treated gastric cancer cells. Since PI3K/Akt/ mTOR plays an important role in progression andtumorigenesis, we also investigated the effect of TQ on PI3K/Akt/mTOR signalling pathway in gastric cancer cells. It wasobserved that TQ down-regulated the expression of some of the key proteins of this pathway. Taken together, we concludethat TQ may prove lead molecule for the treatment of gastric cancer.

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