• Priyakshi Mahanta

      Articles written in Journal of Biosciences

    • FUMET: A fuzzy network module extraction technique for gene expression data

      Priyakshi Mahanta Hasin Afzal Ahmed Dhruba Kumar Bhattacharyya Ashish Ghosh

      More Details Abstract Fulltext PDF

      Construction of co-expression network and extraction of network modules have been an appealing area of bioinformatics research. This article presents a co-expression network construction and a biologically relevant network module extraction technique based on fuzzy set theoretic approach. The technique is able to handle both positive and negative correlations among genes. The constructed network for some benchmark gene expression datasets have been validated using topological internal and external measures. The effectiveness of network module extraction technique has been established in terms of well-known p-value, Q-value and topological statistics.

    • MIPCE: An MI-based protein complex extraction technique

      Priyakshi Mahanta Dhruba K R Bhattacharyya Ashish Ghosh

      More Details Abstract Fulltext PDF

      Protein–protein interaction (PPI) networks are believed to be important sources of information related to biological processes and complex metabolic functions of the cell. Identifying protein complexes is of great importance for understanding cellular organization and functions of organisms. In this work, a method is proposed, referred to as MIPCE, to find protein complexes in a PPI network based on mutual information. MIPCE has been biologically validated by GO-based score and satisfactory results have been obtained. We have also compared our method with some well-known methods and obtained better results in terms of various parameters such as precession, recall and F-measure.

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