Prim B Singh
Articles written in Journal of Biosciences
Volume 40 Issue 2 June 2015 pp 325-338 Articles
Mammals have three HP1 protein isotypes HP1𝛽 (CBX1), HP1𝛾 (CBX3) and HP1𝛼 (CBX5) that are encoded by the corresponding genes
Volume 41 Issue 4 December 2016 pp 759-786 REVIEW
Twenty five years ago it was proposed that conserved components of constitutive heterochromatin assemble heterochromatinlikecomplexes in euchromatin and this could provide a general mechanism for regulating heritable (cell-to-cell) changesin gene expressibility. As a special case, differences in the assembly of heterochromatin-like complexes on homologouschromosomes might also regulate the parent-of-origin-dependent gene expression observed in placental mammals. Here,the progress made in the intervening period with emphasis on the role of heterochromatin and heterochromatin-likecomplexes in parent-of-origin effects in animals is reviewed.
Volume 44 Issue 4 September 2019 Article ID 0106 Mini-Review
It has been proposed that age reprogramming enables old cells to be rejuvenated without passage through an embryonicstage (Singh and Zacouto in J. Biosci. 35 315–319, 2010). As such, age reprogramming stands apart from the inducedpluripotent stem (iPS) and nuclear transfer-embryonic stem (NT-ES) cell therapies where histo-compatible cells are producedonly after passage through an embryonic stage. It avoids many of the disadvantages associated with iPS and NT-EScell therapies. Experimental evidence in support of age reprogramming is burgeoning. Here, we discuss possible newapproaches to enhance age reprogramming, which will have considerable benefits for regenerative therapies.
Volume 45, 2020
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