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PRAKASH DESHPANDE
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Volume 46 All articles Published: 4 August 2021 Article ID 0077 Article
AARTI OZARKAR ABHISHEK KANYAL SWATI DASS PRAKASH DESHPANDE DEEPTI DEOBAGKAR KRISHANPAL KARMODIYA
The global emergence and spread of malaria parasites resistant to antimalarial drugs is a major problem inmalaria control and elimination. In this study, samples from Pune district were characterized to determineprevalence of molecular markers of resistance to chloroquine (pfcrt codons C72S, M74I, N75E, K76T andpfmdr-1 N86Y, Y184F), pyrimethamine (pfdhfr C50R, N51I, C59R, S108N), sulfadoxine (pfdhps, S436A,A437G, K540E, A581G), and artemisinin (pfkelch13, C580Y, R539T). The pfcrt K76T mutation was found in78% samples as CVMNT, SVMNT and CVIET haplotype. The pfmdr-1 N86Y and Y184F mutations werefound in 54% of samples. The pfdhfr double mutation C59R + S108N was present in 67% of samples, whilethe pfdhfr triple mutation (N51I + C59R + S108N) was not detected. The pfdhps mutations A437G andK540E were found in 67% of samples. Single mutants of pfdhps were rare, with K540E detected in only 6patient samples. Similarly, pfdhps A581G was found in 13 of the isolates. The molecular markers associatedwith artemisinin resistance (mutations in pfkelch13 C580Y, R539T) were not detected in any of the isolates.These results suggest an emerging problem with multidrug-resistant P. falciparum. Though the genotypeconventionally associated with artemisinin resistance was not observed, chloroquine-resistant genotype hasreached complete fixation in the population. Moreover, the prevalence of mutations in both pfdhfr and pfdhps,with the presence of the quadruple mutant, indicates that continued monitoring is required to assess whethersulfadoxine-pyrimethamine can be used efficiently as a partner drug for artemisinin for the treatment of P.falciparum.
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Journal of Biosciences
Volume 48, 2023
All articles
Continuous Article Publishing mode
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Journal of Biosciences | News
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To trigger further research on plant mitochondria, the Journal of Biosciences is bringing out a special issue titled "Plant Mitochondria: Properties and Interactions with Other Organelles".
Plant mitochondria are quite distinct and have unique features, such as a cyanide-insensitive alternate pathway. They also interact with chloroplasts to optimize photosynthetic carbon assimilation.
Submissions are welcome until 30 July 2023. The contributions can be original articles, short communications, reviews, or mini-reviews on any topic related to plant mitochondria.
Authors can submit their articles online at https://www.editorialmanager.com/jbsc/default2.aspx
Posted on April 12, 2023< -
Editorial Note on Continuous Article Publication
Posted on July 25, 2019Click here for Editorial Note on CAP Mode
Forthcoming Special issue.
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