• P R Narayanan

      Articles written in Journal of Biosciences

    • Humoral immune response to filarial antigens in chyluria

      Alamelu Raja Rabia Hussain R Prabhakar P R Narayanan

      More Details Abstract Fulltext PDF

      Humoral immune parameters like total immunoglobulins and specific antibody levels in serum were studied in filarial chyluria patients. Mean serum IgG was significantly reduced in this group compared to normal controls, while IgA and IgM levels remained comparable to controls. Anti-filarial antibody titre as measured by enzyme-linked immunosorbent assay also was significantly reduced. However, the total and specific IgE antibody titre was similar to that of controls. Specific IgE contents of the patients’ sera could be related to their microfilaraemic status.

    • Effect of oral exposure ofMycobacterium avium intracellular on the protective immunity induced by BCG

      Sujatha Narayanan C N Paramasivan R Prabhakar P R Narayanan

      More Details Abstract Fulltext PDF

      The relative protective efficacy of oral administration of mycobacteria as compared to the conventional intradermal route of vaccination has been assessed in guinea pigs. Skin test reactivity to partially purified protein derivative and protective immunity to challenge with virulentMycobacterium tuberculosis were used as parameters of protective immunity.

      Oral immunisation of guinea pigs either with BCG or withMycobacterium avium intracellulare induces skin test reactivity and protective immunity comparable to that induced by intradermal route of vaccination. Oral exposure ofMycobacterium avium intracellulare prior to oral or intradermal dose of BCG did not interfere with the protective immunity induced by BCG in guinea pigs challenged withMycobacterium tuberculosis H37Rv.

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