Articles written in Journal of Biosciences

    • Spatial regulation and generation of diversity in signaling pathways


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      Signaling pathways orchestrate diverse cellular outcomes in the same tissue, spatially and temporally. Theseinteractions, which are played out in micro-environments within cells and involve a relatively small number ofcore pathways, are the key to the development and function of multi-cellular organisms. How these outcomesare regulated has prompted interest in intracellular mechanisms that build diversity in signaling outcomes. Thisreview specifically addresses spatial positioning of molecules as a means of enabling interactions and noveloutcomes of signaling cascades. Using the Notch and Ras pathways as exemplars, we describe mechanismsthat contribute to diverse signaling outcomes.

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