• NEETU SAINI

      Articles written in Journal of Biosciences

    • Spatial regulation and generation of diversity in signaling pathways

      NEETU SAINI APURVA SARIN

      More Details Abstract Fulltext PDF

      Signaling pathways orchestrate diverse cellular outcomes in the same tissue, spatially and temporally. Theseinteractions, which are played out in micro-environments within cells and involve a relatively small number ofcore pathways, are the key to the development and function of multi-cellular organisms. How these outcomesare regulated has prompted interest in intracellular mechanisms that build diversity in signaling outcomes. Thisreview specifically addresses spatial positioning of molecules as a means of enabling interactions and noveloutcomes of signaling cascades. Using the Notch and Ras pathways as exemplars, we describe mechanismsthat contribute to diverse signaling outcomes.

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