Breast cancer is the second leading cause of cancer-related death among females, worldwide. The cytokines areproteins that have a significant role in the development of tumor growth. Leukemia inhibitory factor (LIF) ofthe interleukin-6 cytokines superfamily plays a significant role, by the modulation of many signaling pathways.This study summarizes some current works in breast cancer, in which LIF intervention is being discussed. LIFpromotes tumorigenesis, invasion, migration of breast cancer cells in vitro, metastasis of breast cancer in vivo,epithelial-mesenchymal transition, and mediates pro-invasive activation of stromal fibroblast. LIF contributesto inducing growth, tumorigenesis, and metastasis of breast cancer and is a significant biomarker for breasttumors and can be a therapeutic target for clinical intervention.