Michel Morange
Articles written in Journal of Biosciences
Volume 29 Issue 4 December 2004 pp 378-380 Commentary
The death of Francis Crick: the end of a golden age in biology
Volume 30 Issue 3 June 2005 pp 313-316 Series
The history of science was long considered to be something peripheral to science itself. By supplying interesting stories and gossip, it seemed, at best, to provide material for enlivening lectures. In general, it was deemed a suitable activity for retired scientists. This view has been revised considerably in the past years and indeed, today seems hopelessly out of date. History and philosophy of science are increasingly held to be an essential component of the education of scientists. By becoming acquainted with these areas, practicing scientists — and in particular biologists — can better appreciate the significance of the models and theories that underpin their research, especially with the accelerating succession of one idea by the next. The present series, of which the article that follows is the first, aims to give historical glimpses that bear on contemporary biology. The hope is that these glimpses will be both a source of inspiration and of help in resisting useless fashions.
Volume 30 Issue 4 September 2005 pp 461-464 Series
What history tells us II. The discovery of chaperone function
Volume 30 Issue 5 December 2005 pp 591-594 Series
What history tells us III. André Lwoff: From protozoology to molecular definition of viruses
Volume 31 Issue 1 March 2006 pp 27-30 Series
Volume 31 Issue 2 June 2006 pp 215-218 Series
What history tells us V. Emile Duclaux (1840–1904)
Perhaps we should be more cautions in our vision of how a scientist should behave, a perception closely tied to the present-day organization of scientific research — with its extreme specialization. Is the present situation optimal? And was not the huge spectrum of activities and interests of Emile Duclaux also necessary for the rapid development of microbiology and its general acceptance? We should not reduce the history of medicine to a catalog of the discoverers of diseases. As a scientific organizer, and a prime mover in the development of microbiology, Emile Duclaux deserves a place in our memories.
Volume 31 Issue 3 September 2006 pp 323-327 Series
What history tells us VI. The transfer of behaviours by macromolecules
Volume 31 Issue 5 December 2006 pp 537-541 Series
What history tells us VII. Twenty-five years ago: The production of mouse embryonic stem cells
Volume 32 Issue 2 March 2007 pp 223-227 Series
What history tells us VIII. The progressive construction of a mechanism for prion diseases
Volume 32 Issue 4 June 2007 pp 657-661 Series
What history tells us IX. Z-DNA: when nature is not opportunistic
Volume 32 Issue 6 September 2007 pp 1083-1087 Series
What history tells us X. Fifty years ago: the beginnings of exobiology
Volume 32 Issue 7 December 2007 pp 1245-1250 Series
What history tells us XI. The complex history of the chemiosmotic theory
Volume 33 Issue 1 March 2008 pp 21-25 Series
Volume 33 Issue 2 June 2008 pp 171-175 Series
What history tells us XIII. Fifty years of the Central Dogma
Volume 33 Issue 3 September 2008 pp 327-331 Series
What history tells us XIV. Regulation of gene expression by non-coding RNAs: the early steps
Volume 33 Issue 5 December 2008 pp 669-672 Series
Volume 34 Issue 1 March 2009 pp 17-20 Series
What history tells us XVI. A third pillar for molecular biology: Molecular embryology
Volume 34 Issue 2 June 2009 pp 195-198 Series
What history tells us XVII. Conrad Waddington and
Volume 34 Issue 3 September 2009 pp 373-376 Series
What history tells us XVIII. When functional biologists propose mechanisms of evolution
Volume 34 Issue 4 October 2009 pp 495-501 Articles
How phenotypic plasticity made its way into molecular biology
Phenotypic plasticity has been fashionable in recent years. It has never been absent from the studies of evolutionary biologists, although the availability of stable animal models has limited its role. Although opposed by the reductionist and deterministic approach of molecular biology, phenotypic plasticity has nevertheless recently made its way into this discipline, in particular through the limits of the molecular description. Its resurrection has been triggered by a small group of theoreticians, the rise of epigenetic descriptions and the publicized discovery of stem cell plasticity. The notion of phenotypic plasticity remains vague. History shows that too strong a belief in plasticity can be an obstacle to the development of biology. Two important questions are still pending: the link between the different forms of plasticity present at different levels of organization, and the relation, if any, between the modular organization of organisms and phenotypic plasticity. Future research will help to discriminate between possible and actual mechanisms of phenotypic plasticity, and to give phenotypic plasticity its real place in the living world.
Volume 34 Issue 6 December 2009 pp 845-848 Series
What history tells us XIX. The notion of the episome
Volume 35 Issue 1 March 2010 pp 17-20 Series
Volume 35 Issue 2 June 2010 pp 177-181 Series
Volume 35 Issue 4 December 2010 pp 515-517 Series
What history tells us XXII. The French neo-Lamarckians
Volume 36 Issue 1 March 2011 pp 23-26 Series
Volume 36 Issue 2 June 2011 pp 211-214 Series
Volume 36 Issue 4 September 2011 pp 571-574 Series
Volume 36 Issue 5 December 2011 pp 769-772 Series
Volume 37 Issue 1 March 2012 pp 13-17 Series
What history tells us XXVII. A new life for allostery
Volume 37 Issue 4 September 2012 pp 609-612 Series
What history tells us XXVIII. What is really new in the current evolutionary theory of cancer?
Volume 37 Issue 6 December 2012 pp 949-952 Series
Volume 38 Issue 1 March 2013 pp 3-7 Series
What history tells us XXX. The emergence of the fluid mosaic model of membranes
Volume 38 Issue 2 June 2013 pp 225-227 Series
What history tells us XXXI. The replicon model: Between molecular biology and molecular cell biology
Volume 38 Issue 3 September 2013 pp 451-454 Series
What history tells us XXXII. The long and tortuous history of epigenetic marks
Volume 39 Issue 1 March 2014 pp 29-32 Series
Volume 39 Issue 3 June 2014 pp 347-350 Series
What history tells us XXXIV. The complex history of the selective model of antibody formation
Volume 39 Issue 5 December 2014 pp 741-745 Series
Volume 40 Issue 1 March 2015 pp 3-6 Series
What history tells us XXXVI. Reverse transcriptase and Lamarckian scenarios of evolution
Volume 40 Issue 2 June 2015 pp 221-223 Series
What history tells us XXXVII. CRISPR-Cas: The discovery of an immune system in prokaryotes
Volume 40 Issue 3 September 2015 pp 473-476 Series
What history tells us XXXVIII. Resurrection of a transient forgotten model of gene action
Volume 40 Issue 5 December 2015 pp 829-832 Series
Volume 41 Issue 1 March 2016 pp 9-11 Series
What history tells us XL. The success story of the expression ‘genome editing’
Volume 41 Issue 3 September 2016 pp 325-330 Series
What history tells us XLI. Ubiquitin and proteolysis
Volume 42 Issue 1 March 2017 pp 11-14 Series
What history tells us XLII. A ‘new’ view of proteins
Volume 42 Issue 3 September 2017 pp 359-362 Series
What history tells us XLIII Bacteriophage: The contexts in which it was discovered
Volume 42 Issue 4 December 2017 pp 527-530 Series
What history tells us XLIV: The construction of the zinc finger nucleases
Volume 43 Issue 2 June 2018 pp 229-233 Series
What history tells us XLV. The ‘instability’ of messenger RNA
Volume 48, 2023
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