• Mahatab S Bamji

      Articles written in Journal of Biosciences

    • Interactions of progesterone with D-amino acid oxidase—different effects on apo- and holo-enzyme

      Faizy Ahmed Mahatab S Bamji

      More Details Abstract Fulltext PDF

      A simple method using charcoal treatment was developed for the preparation of apo-D-amino acid oxidase from rat kidney homogenates. This apo-D-amino acid oxidase was used to study the effect of progesterone on the apo- and holo-enzyme. Progesterone inhibited the activity of D-amino acid oxidase, when the apo-enzyme, preincubated with saturating amounts of FAD was used; this effect varied with FAD concentration. Progesterone did not inhibit the activity when added to a mixture of non-preincubated apo-enzyme and FAD; this suggests that progesterone has different effects on apo- and holo D-amino acid oxidase.

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