Articles written in Journal of Biosciences
Volume 32 Issue 5 August 2007 pp 1009-1017 Articles
Signalling pathways are complex biochemical networks responsible for reg ulation of numerous cellular functions. These networks function by serial and successive interactions among a large number of vital biomolecules and chemical compounds. For deciphering and analysing the underlying mechanism of such networks, a modularized study is quite helpful. Here we propose an algorithm for modularization of calcium signalling pathway of
Volume 43 Issue 5 December 2018 pp 1037-1054 Research Resource
The human brain and its temporal behavior correlated with development, structure, and function is a complex naturalsystem even for its own kind. Coding and automation are necessary for modeling, analyzing and understanding the 86.1 ±8.1 billion neurons, an almost equal number of non-neuronal glial cells, and the neuronal networks of the human braincomprising about 100 trillion connections. ‘Computational neuroscience’ which is heavily dependent on biology, physics,mathematics and computation addresses such problems while the archival, retrieval and merging of the huge amount ofgenerated data in the form of clinical records, scientific literature, and specialized databases are carried out by ‘neuroinformatics’approaches. Neuroinformatics is thus an interface between computer science and experimental neuroscience.This article provides an introduction to computational neuroscience and neuroinformatics fields along with their state-ofthe-art tools, software, and resources. Furthermore, it describes a few innovative applications of these fields in predictingand detecting brain network organization, complex brain disorder diagnosis, large-scale 3D simulation of the brain, brain–computer, and brain-to-brain interfaces. It provides an integrated overview of the fields in a non-technical way, appropriatefor broad general readership. Moreover, the article is an updated unified resource of the existing knowledge and sources forresearchers stepping into these fields.