• KAPAETTU SATYAMOORTHY

      Articles written in Journal of Biosciences

    • Exploring the signature gut and oral microbiome in individuals of specific Ayurveda prakriti

      TIRUMALAPURA VIJAYANNA SHALINI APOORVA JNANA SITARAM JAIDEEP SRIRANJINI ANKIT SINGH TANWAR ANGELA BRAND THOKUR SREEPATHY MURALI KAPAETTU SATYAMOORTHY G G GANGADHARAN

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      Diagnosis and treatment of various diseases in Ayurveda, the Indian system of medicine, relies on ‘prakriti’phenotyping of individuals into predominantly three constitutions, kapha, pitta and vata. Recent studiespropose that microbiome play an integral role in precision medicine. A study of the relationship betweenprakriti – the basis of personalized medicine in Ayurveda and that of gut microbiome, and possible biomarkerof an individual’s health, would vastly improve precision therapy. Towards this, we analyzed bacterialmetagenomes from buccal (oral microbiome) and fecal (gut microbiome) samples of 272 healthy individuals ofvarious predominant prakritis. Major bacterial genera from gut microbiome included Prevotella, Bacteroidesand Dialister while oral microbiome included Streptococcus, Neisseria, Veilonella, Haemophilus, Porphyromonasand Prevotella. Though the core microbiome was shared across all individuals, we found prakritispecific signatures such as preferential presence of Paraprevotella and Christensenellaceae in vata individuals.A comparison of core gut microbiome of each prakriti with a database of ‘healthy’ microbes identifiedmicrobes unique to each prakriti with functional roles similar to the physiological characteristics of variousprakritis as described in Ayurveda. Our findings provide evidence to Ayurvedic interventions based on prakritiphenotyping and possible microbial biomarkers that can stratify the heterogenous population and aid inprecision therapy.

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