• K Madhusudan

      Articles written in Journal of Biosciences

    • Alignment and phylogenetic analysis of type II DNA topoisomerases

      K Madhusudan V Nagaraja

      More Details Abstract Fulltext PDF

      DNA topoisomerases have been evolved to solve the topological problems of DNA during replication, transcription, recombination and segregation. Discovery of several new enzymes and their characterization has necessitated this compilation. This analysis shows the distinct evolutionary relatedness of type II DNA topoisomerases. A striking feature is the absence of a contiguous stretch of about 160 amino acids in one of the subunits of prokaryotic type II enzymes, which might have important implications to their structure and function.

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