Articles written in Journal of Biosciences
Volume 42 Issue 4 December 2017 pp 671-681 Article
Lung cancer is the leading cause of cancer-related death throughout the world. We aimed to investigate the role of a novelmicroRNA-876-5p and its potential molecular target bone morphogenetic protein 4 (BMP-4), in the epithelial–mesenchymaltransition (EMT) of lung cancer. Expressions of microRNA-876-5p and its potential target BMP-4 were analysedin lung cancer cells and patient tissues. Luciferase activity assay was conducted to verify direct targeting of microRNA-876-5p to the 30-UTR of BMP-4 mRNA. Migration, invasion capacities of lung cancer cells expressing microRNA-876-5pwere analysed, and characteristics of lung cancer EMT protein markers were also evaluated. A xenograft tumour mousemodel was established to address the roles of microRNA-876-5p and BMP-4 in lung cancer EMT in vivo. MicroRNA-876-5p was decreased while BMP-4 was increased in lung cancer cells and tissues. MicroRNA-876-5p directly targeted 30-UTRof BMP-4 mRNA to inhibit its expression. MicroRNA-876-5p expression significantly inhibited the migration, invasionand EMT of lung cancer cells in vitro, as well as metastasis in vivo, which required BMP-4 expression. MicroRNA-876-5psuppresses EMT of lung cancer by directly down-regulating BMP-4, both of which could serve as potential therapeutictargets in the treatment of lung cancer.
Volume 45, 2020
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