JAYASRI DAS SARMA
Articles written in Journal of Biosciences
Volume 42 Issue 2 June 2017 pp 231-244 Article
Intracellular trafficking and localization studies of spike protein from SARS and OC43 showed that SARS spikeprotein is localized in the ER or ERGIC compartment and OC43 spike protein is predominantly localized in thelysosome. Differential localization can be explained by signal sequence. The sequence alignment using Clustal Wshows that the signal sequence present at the cytoplasmic tail plays an important role in spike protein localization. Aunique GYQEL motif is identified at the cytoplasmic terminal of OC43 spike protein which helps in localization in thelysosome, and a novel KLHYT motif is identified in the cytoplasmic tail of SARS spike protein which helps in ER orERGIC localization. This study sheds some light on the role of cytoplasmic tail of spike protein in cell-to-cell fusion,coronavirus host cell fusion and subsequent pathogenicity.
Volume 43 Issue 5 December 2018 pp 1055-1068 Review
The gap junctions (GJs), which form intercellular communicating channels between two apposing cells or formhemichannel with extracellular environment, perform crucial functions to maintain small molecule homeostasis. Thecentral nervous system (CNS) GJs are important for maintenance of myelin sheath and neuronal activity. Connexin (Cx)proteins are building blocks of GJs. Recent cell-biological investigations show that amongst the CNS specific Cxs, themost abundant Cx protein, Cx43 and its oligodendrocytic coupling partner Cx47 primarily important for maintenance ofCNS myelin. Recent investigations elucidate that the expression of Cx43 and Cx47 is very important to maintain K?buffering and nutrient homeostasis in oligodendrocytes, CNS myelin and oligodendrocyte function. The investigationson Multiple Sclerosis (MS) patient samples and EAE hypothesized that the functional loss of Cx43/Cx47 could beassociated with spread of chronic MS lesions. Exploring the mechanism of initial GJ alteration and its effect ondemyelination in this model of MS might play a primary role to understand the basis of altered CNS homeostasis,observed during MS. In this review, we mainly discuss the role of CNS GJs, specifically the Cx43/Cx47 axis in theperspective of demyelination.
Volume 45, 2020
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