• ISAAC ARNOLD EMERSON

      Articles written in Journal of Biosciences

    • Dynamic conformational flexibility and molecular interactions of intrinsically disordered proteins

      ANIL BHATTARAI ISAAC ARNOLD EMERSON

      More Details Abstract Fulltext PDF

      Intrinsically disordered proteins (IDPs) are highly flexible and undergo disorder to order transition uponbinding. They are highly abundant in human proteomes and play critical roles in cell signaling and regulatoryprocesses. This review mainly focuses on the dynamics of disordered proteins including their conformationalheterogeneity, protein–protein interactions, and the phase transition of biomolecular condensates that arecentral to various biological functions. Besides, the role of RNA-mediated chaperones in protein folding andstability of IDPs were also discussed. Finally, we explored the dynamic binding interface of IDPs as noveltherapeutic targets and the effect of small molecules on their interactions.

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