• IAN K HART

      Articles written in Journal of Biosciences

    • Immunophenotypical characterization of paraneoplastic neurological syndrome patients: a multicentric study

      LORENZO LORUSSO VINCENZA PRECONE IAN K HART BRUNO GIOMETTO RAFFAELE PEZZANI GAELLE K NGONGA STEFANO PAOLACCI DANIELA FERRARI GIOVANNI RICEVUTI ERNIE MARSHALL MATTEO BERTELLI

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      Paraneoplastic neurological syndromes (PNS) are a group of rare and severe immune-mediated disorders thataffect the nervous system in patients with cancer. The best way to diagnose a paraneoplastic neurologicaldisorder is to identify anti-onconeural protein antibodies that are specifically associated with various cancers.The aim of this multicentric study was to clinically and immunologically characterize patients with PNS andstudy their association with cancer. Patients suspected to have PNS were enrolled from various clinical centresand were characterized immunologically. This study population consisted of 112 patients. Onset of PNS wasmainly subacute (76%). PNS patients had various neurological disorders and symptoms. PNS developed beforethe diagnosis of cancer in 28 definite PNS patients and in six suspected PNS patients. The most frequentautoantibodies detected in PNS patients were anti-Hu and anti-Yo. One definite PNS patient with cerebellarsyndrome had anti-Tr antibody and seven patients had atypical antibodies. The literature associates theseantibodies with various neurological disorders and cancers. Our observations confirm the important role ofautoantibodies in PNS and their importance for the early diagnosis of cancer in PNS patients.

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