Articles written in Journal of Biosciences
Volume 40 Issue 2 June 2015 pp 241-255 Articles
Homeobox genes are compared between genomes in an attempt to understand the evolution of animal development. The ability of the protist,
Volume 43 Issue 2 June 2018 pp 351-364 Article
Sirtuins are a family of deacetylases (Class III histone deacetylases) with evolutionarily conserved functions in cellularmetabolism and chromatin regulation. Out of the seven human Sirtuins, the function of Sirt2 is the least understood. Thepurpose of the present study was to investigate the role of Sir2A, a homolog of human Sirt2 in Dictyostelium discoideum(Dd), a lower eukaryote. We created both overexpressing and deletion strains of Ddsir2A to analyse its functions. Weobserved sir2A mRNA expression throughout development and the transcript was present in the prespore/spore region ofmulticellular structures developed. They show a preference towards prestalk/stalk pathway when co-developed with wildtypecells during chimera formation. Deletion strain showed a multi-tipped phenotype, decrease in cell proliferation andinhibition of autophagy. In conclusion, our results show low cAMP levels, reduced cell-adhesion, weak cell migration andimpaired autophagy to be responsible for the phenotype shown by the null cells. This study provides new insights into thefunctions of Ddsir2A.
Volume 44 | Issue 5
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