• HANAN POLANSKY

      Articles written in Journal of Biosciences

    • Dynamics of sequestering the limiting p300/CBP, viral cis-regulatory elements, and disease

      HANAN POLANSKY HAVA SCHWAB

      More Details Abstract Fulltext PDF

      Many studies showed that the p300/CBP coactivator is limiting. Here we review three studies that showed howtranscription complexes formed on viral cis-regulator elements compete with cellular transcription complexesby sequestrating the p300/CBP coactivator. According to the microcompetition model, this sequestering cancause disease. We use the microcompetition model to explain how a specific type of sequestering, caused by alatent virus that has an active cis-regulatory element in its promoter/enhancer that binds the transcriptioncomplex p300/CBP.GABP can cause diseases such as cancer, atherosclerosis, diabetes, and certain autoimmunediseases.

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