G K GOWTHAM
Articles written in Journal of Biosciences
Volume 44 Issue 6 December 2019 Article ID 0135 Article
Nanoparticles (NPs) synthesized by laser ablation in distilled water were used to study their biological effect on normal andcancer cells. Parameters such as cell morphology, cell proliferation and viability were examined for treated cell lines, andthe effect was represented in terms of cells cytotoxicity using standard procedures. The study reveals the higher cytotoxiceffect of nanoparticles on cancerous cells of breast, melanoma and colon origin compared to normal fibroblast cells NIH-3T3. Furthermore, DNA fragmentation assay results demonstrated the apoptosis mediated cell death in nanoparticle-treatedcancer cells. The distinct role of nanoparticles in normal and cancer cells of different origin showed that nanoparticles werespecific to cause cytotoxicity in particular cancer cells type. NPs exhibit cytotoxic effects in cancer cells by inducingapoptosis. These studies provide fundamental evidence for the easy, simple and safe mode of nanoparticles synthesis andtheir application in cancer cells death.
Volume 45, 2020
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