G P Talwar
Articles written in Journal of Biosciences
Volume 4 Issue 1 March 1982 pp 105-113
Properties and characteristics of an anti-human chorionic gonadotropin monoclonal antibody
S K Gupta S Ramakrishnan G P Talwar
The product of a hybrid cell clone, P3W80, obtained as ascites fluid from mouse peritoneal cavity had high titres of anti-human chorionic gonadotropin antibodies e.g. 30 to 40% binding of125I-human chorionic gonadotropin at 107 dilution in a radioimmunoassay. The antiserum SB6 (raised against Β-human chorionic gonadotropin distributed by National Institutes of Health, USA gave similar binding at 5000 dilution in parallel runs. The monoclonal antibody recognized best human chorionic gonadotropin (0.3 mlU of hormone/tube with
Volume 7 Issue 2 March 1985 pp 105-113
Diversity of antigenic determinants of porcine zona pellucida revealed by monoclonal antibodies
A K Bamezai A Bhattacharya A H Band Suman G P Talwar
Monoclonal antibodies derived from ten hybrid cell clones, generated against porcine zona pellucida gave strong immunofluorescence with zona but the pattern varied from patchy, thin rim to heavy precipitation type of rim. Five of the 6 monoclonals studied prevented the binding of the porcine epididymal sperm to homologous oocytes
Volume 10 Issue 4 December 1986 pp 481-486
Cloning of Y derived DNA sequences of bovine origin in
Pramod Khandekar G P Talwar Renu Chaudhury
We have constructed a partial library of Y chromosome derived DNA sequences of bovine origin in
Volume 12 Issue 4 December 1987 pp 349-357
Isolation and characterization of cDNA clones for α- and β-subunits of ovine luteinizing hormone
Swatantra K Jain William W Chin G P Talwar
A cDNA library of ovine pituitary DNA in plasmid pBR322 has been constructed by conventional methods with certain modifications. The library was screened using partial cDNAs for rat
Volume 30 Issue 4 September 2005 pp 435-447 Perspectives
Volume 34 Issue 6 December 2009 pp 909-916 Articles
Hemant Kumar Vyas Rahul Pal Nirmal K Lohiya G P Talwar
A number of therapeutic options are available for patients with prostate carcinoma till the time that the tumour is hormone dependent. However, no fully effective therapy is available for the treatment of androgen-independent prostate carcinomas. Antibodies directed at epitopes unique to or overexpressed on the cancer cells could be of therapeutic utility. A monoclonal antibody (Moab) 2C4 has been generated, which binds with cells of two androgenindependent prostate cancers, DU145 and PC3, and does not bind to peripheral blood leukocytes (PBLs) of healthy donors. This antibody, along with the previously developed Moab 730, kills 100% of both DU145 and PC3 cells in the presence of complement and does not have a deleterious effect on PBLs of healthy males. The anti-tumour action of the two antibodies prevents the establishment of DU145 cell tumour in nude mice in vivo. Moab 2C4 in combination with 730 has potential for use as therapy for androgen-independent cancers.
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