• DONG ZHAO

      Articles written in Journal of Biosciences

    • α-Helical protein absorption at post-traumatic epileptic foci monitored by Fourier transform infrared mapping

      SIYANG XIANG DONG ZHAO HONGXIA HAO XU WANG LING LI TIANTONG YANG

      More Details Abstract Fulltext PDF

      Tissue analysis by Fourier transform infrared (FTIR) imaging can determine the biodistribution of molecules,without pre-analytical modification. We aimed to study the infrared spectroscopic changes of α-helical proteinsat post-traumatic epileptic (PTE) foci by FTIR. FITR mapping was applied to detect α-helical proteins in ratbrain tissue samples with post-traumatic epilepsy. Histological examination of brain sections showed that therat model of PTE was successfully established. At the PTE foci, high α-helical absorption regions wereevident, where the color difference and absorption were significantly different from those in the low-absorptionregions. This provided a distinctive and characteristic pattern at the site of lesions. The use of FTIR imagingmeans that it is possible to measure the molecular structural changes resulting from PTE pathologies in tissues,providing a novel adjunct to conventional pathological diagnostic techniques.

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