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DEEPAK SHARMA
Articles written in Journal of Biosciences
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Volume 24 Issue S1 March 1999 pp 33-198
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Volume 32 Issue 2 March 2007 pp 185-189
Deepak Sharma Jaya Sivaswami Tyagi
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Volume 48 All articles Published: 27 March 2023 Article ID 0009 Article
RAGHAVENDRA S PATWARDHAN KSHAMA KUNDU VAITASHI PUROHIT BINITA KISLAY KUMAR BEENA SINGH MAIKHO THOH KHUSHBOO UNDAVIA HARI N BHILWADE SANDIP K NAYAK DEEPAK SHARMA SANTOSH K SANDUR
The present study primarily focuses on the efficacy of Malabaricone C (Mal C) as an anti-inflammatory agent. Mal C inhibited mitogen-induced T-cell proliferation and cytokine secretion. Mal C significantly reduced cellular thiols in lymphocytes.
N -acetyl cysteine (NAC) restored cellular thiol levels and abrogated Mal C-mediated inhibition of T-cell proliferation and cytokine secretion. Physical interaction between Mal C and NAC was evinced from HPLC and spectral analysis. Mal C treatment significantly inhibited concanavalin A-induced phosphorylation of ERK/JNK and DNA binding of NF-κB. Administration of Mal C to mice suppressed T-cell proliferation and effector functionsex vivo . Mal C treatment did not alter the homeostatic proliferation of T-cellsin vivo but completely abrogated acute graft-versus-host disease (GvHD)-associated morbidity and mortality. Our studies indicate probable use of Mal C for prophylaxis and treatment of immunological disorders caused due to hyper-activation of T-cells.
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Journal of Biosciences
Volume 48, 2023
All articles
Continuous Article Publishing mode
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Journal of Biosciences | News
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To trigger further research on plant mitochondria, the Journal of Biosciences is bringing out a special issue titled "Plant Mitochondria: Properties and Interactions with Other Organelles".
Plant mitochondria are quite distinct and have unique features, such as a cyanide-insensitive alternate pathway. They also interact with chloroplasts to optimize photosynthetic carbon assimilation.
Submissions are welcome until 30 July 2023. The contributions can be original articles, short communications, reviews, or mini-reviews on any topic related to plant mitochondria.
Authors can submit their articles online at https://www.editorialmanager.com/jbsc/default2.aspx
Posted on April 12, 2023< -
Editorial Note on Continuous Article Publication
Posted on July 25, 2019Click here for Editorial Note on CAP Mode
Forthcoming Special issue.
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