C K Ramakrishna Kurup
Articles written in Journal of Biosciences
Volume 11 Issue 1-4 March 1987 pp 391-397
It is shown for the first time that the content of ubiquinone of liver increases (2.5 fold) on dietary administration of the widely-used industrial Plasticizer diethylhexyl Phthalate to the rat. The increase is localized almost entirely in mitochondria in which the concentration of the quinone Per mg Protein is 1.7 times the control. IncorPoration of the radioactive Precursor (acetate) reveals that the biosynthesis of ubiquinone is increased in the livers of Plasticizer-administered animals. The rate of degradation is not altered.
Volume 15 Issue 3 September 1990 pp 205-210
The activities of calcium-stimulated respiration, calcium uptake, α-glycero-phosphate dehydrogenase and rates of oxidation in state 3 and of H2O2 generation, were found to increase and that of pyruvate dehydrogenase decrease in mitochondria isolated from livers of rats administered intraperitoneally or perfused with polyvanadate. Phenoxybenzamine, an antagonist of α-adrenergic receptor, effectively prevented these changes. It was also found that perfusion of the liver with polyvanadate reproduced one of the best characterized events of α-adrenergic activation-stimulation of protein kinase C in plasma membrane accompanied by its decrease in cytosol. These experiments indicate for the first time the α-adrenergic mimetic action of polyvanadate.
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