• Bellur Seetharam

      Articles written in Journal of Biosciences

    • How does cobalamin (vitamin B12) enter and traverse mammalian cells?

      Bellur Seetharam

      More Details Abstract Fulltext PDF

      This overview is intended to present recent information available on the work done in understanding the mode of entry of cobalamin into and out of mammalian cells. I have focused primarily on the uptake of cobalamin bound to 3 proteins: intrinsic factor, transcobalamin II and R-proteins. Even though the nature of these cobalamin binding proteins, and the receptors involved in the internalization of these proteins is known, a total picture on the intracellular trafficking of cobalamin and the binding proteins is far from complete.

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