Articles written in Journal of Biosciences
Volume 11 Issue 1-4 March 1987 pp 75-80
This overview is intended to present recent information available on the work done in understanding the mode of entry of cobalamin into and out of mammalian cells. I have focused primarily on the uptake of cobalamin bound to 3 proteins: intrinsic factor, transcobalamin II and R-proteins. Even though the nature of these cobalamin binding proteins, and the receptors involved in the internalization of these proteins is known, a total picture on the intracellular trafficking of cobalamin and the binding proteins is far from complete.
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