• BIRENDRA SINGH YADAV

      Articles written in Journal of Biosciences

    • Interaction network analysis of YBX1 for identification of therapeutic targets in adenocarcinomas

      SURIYA NARAYANAN MURUGESAN BIRENDRA SINGH YADAV PRAMOD KUMAR MAURYA AMIT CHAUDHARY SWATI SINGH ASHUTOSH MANI

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      Human Y-box binding protein-1 (YBX1) is a member of highly conserved cold-shock domain protein family, which isinvolved in transcriptional as well as translational regulation of many genes. Nuclear localization of YBX1 has beenobserved in various cancer types and it’s overexpression has been linked to adverse clinical outcome and poor therapyresponse, but no diagnostic or therapeutic correlation has been established so far. This study aimed to identify differentiallyexpressed novel genes among the interactors of YBX1 in different cancer types. Analysis of RNA-Seq data for colorectal,lung, prostate and stomach adenocarcinoma identified 39 unique genes, which are differentially expressed in the fouradenocarcinoma types. Gene-enrichment analysis for the differentially expressed genes from individual adenocarcinomawith focus on unique genes resulted in a total of 57 gene sets specific to each adenocarcinoma. Gene ontology forcommonly expressed genes suggested the pathways and possible mechanisms through which they affect each adenocarcinomatype considered in the study. Gene regulatory network constructed for the common genes and network topologywas analyzed for the central nodes. Here 12 genes were found to play important roles in the network formation; amongthem, two genes FOXM1 and TOP2A were found to be in central network formation, which makes them a common targetfor therapeutics. Furthermore, five common differentially expressed genes in all adenocarcinomas were also identified.

    • Analysis of chickpea gene co-expression networks and pathways during heavy metal stress

      BIRENDRA SINGH YADAV SWATI SINGH SAMEER SRIVASTAVA ASHUTOSH MANI

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      Crop productivity and yield are adversely affected by abiotic and biotic stresses. Therefore, finding out the genesresponsible for stress tolerance is a significant stride towards crop improvement. A gene co-expression network is apowerful tool to detect the most connected genes during heavy metal (HM) stress in plants. The most connected genes maybe responsible for HM tolerance by altering the different metabolic pathways during the biotic and abiotic stress. In thesame line we have performed the GSE86807 microarray analysis of chickpea during exposure to chromium, cadmium andarsenic and analyzed the data. Common differentially expressed genes (DEGs) during exposure to chromium, cadmium andarsenic were identified and a co-expression network study was carried out. Hub and bottleneck genes were explored on thebasis of degree and betweenness centrality, respectively. A gene set enrichment analysis study revealed that genes likehaloacid dehydrogenase, cinnamoyl CoA reductase, F-box protein, GDSL esterase lipase, cellulose synthase, b-glucosidase13 and isoflavone hydroxylase are significantly enriched and regulate the different pathways like riboflavin metabolism,phenyl propanoid biosynthesis, amino acid biosynthesis, isoflavonoid biosynthesis and indole alkaloid biosynthesis.

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