Articles written in Journal of Biosciences
Volume 46 All articles Published: 6 May 2021 Article ID 0042 Review
Alzheimer’s disease (AD) is a devastating neurodegenerative condition provoking the loss of cognitive andmemory performances. Despite huge efforts to develop effective AD therapies, there is still no cure for thisneurological condition. Here, we review the main biological properties of Phycocyanobilin (PCB), accountingfor its potential uses against AD. PCB, given individually or released in vivo from C-Phycocyanin (C-PC), actsas a bioactive-molecule-mediating antioxidant, is anti-inflammatory and has immunomodulatory activities.PCB/C-PC are able to scavenge reactive oxygen and nitrogen species, to counteract lipid peroxidation and toinhibit enzymes such as NADPH oxidase and COX-2. In animal models of multiple sclerosis and ischemicstroke, these compounds induce remyelination as demonstrated by electron microscopy and the expression ofgenes such as Mal up-regulation of and Lingo-1 down-regulation. These treatments also reduce pro-inflammatorycytokines levels and induce immune suppressive genes. PCB/C-PC protects isolated rat brain mitochondriaand inactivate microglia, astrocytes and neuronal apoptosis mediators. Such processes are all involvedin the pathogenic cascade of AD, and thus PCB may effectively mitigate the injury in this condition. Furthermore,PCB can be administered safely by oral or parenteral routes and therefore, could be commerciallyoffered as a nutraceutical supplement or as a pharmaceutical drug.
Volume 46, 2020
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