• Ashok Sharma

      Articles written in Journal of Biosciences

    • Type 2 diabetes mellitus: phylogenetic motifs for predicting protein functional sites

      Ashok Sharma Tanuja Rastogi Meenakshi Bhartiya A K Shasany S P S Khanuja

      More Details Abstract Fulltext PDF

      Diabetes mellitus, commonly referred to as diabetes, is a medical condition associated with abnormally high levels of glucose (or sugar) in the blood. Keeping this view, we demonstrate the phylogenetic motifs (PMs) identification in type 2 diabetes mellitus very likely corresponding to protein functional sites. In this article, we have identified PMs for all the candidate genes for type 2 diabetes mellitus. Glycine 310 remains conserved for glucokinase and potassium channel KCNJ11. Isoleucine 137 was conserved for insulin receptor and regulatory subunit of a phosphorylating enzyme. Whereas residues valine, leucine, methionine were highly conserved for insulin receptor. Occurrence of proline was very high for calpain 10 gene and glucose transporter

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