• Alan John A McBride

      Articles written in Journal of Biosciences

    • Neuropeptide Y gene expression around meal time in the Brazilian flounder Paralichthys orbignyanus

      Vinicius F Campos Ricardo B Robaldo João C Deschamps Fabiana K Seixas Alan John A McBride Luis Fernando Marins Marcelo Okamoto Luís A Sampaio Tiago Collares

      More Details Abstract Fulltext PDF

      Neuropeptide Y (NPY) is considered the major stimulant for food intake in mammals and fish. Previous results indicate that NPY is involved in the feeding behaviour of the Brazilian flounder, Paralichthys orbignyanus. In this study, we evaluated hypothalamic NPY expression before (−2 h), during (0 h) and after feeding (+2 h) in two independent experiments: (1) during a normal feeding schedule and (2) in fish fasted for 2 weeks. During normal feeding, changes in the levels of NPY mRNA were periprandial, with expression levels being significantly elevated at meal time (𝑃 < 0.05) and significantly reduced 2 h later (𝑃< 0.05). Comparing the fasting and unfasted groups, NPY mRNA levels were significantly higher (𝑃 < 0.05) at −2 h and +2 h in the fasting group, but there was no difference at 0 h. In addition, the higher NPY mRNA levels that were observed in the fasting group were maintained throughout the sampling period. In summary, our results show that NPY expression was associated with meal time (0 h) in food intake regulation.

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