• A K Praharaj

      Articles written in Journal of Biosciences

    • Enhanced antibody response to a detergent-soluble antigen in human filariasis after treatment with diethylcarbamazine

      A K Praharaj Manoj K Das

      More Details Abstract Fulltext PDF

      An antigen fraction has been isolated from the water insoluble component of cattle filarial parasiteSetaria digitata by detergent NP-40 solubilization, precipitation with ammonium sulphate and fractionation on sephadex G-100. Immunoglobulin G response to the isolated antigenic fraction was selectively suppressed in asymptomatic microfilaraemic people in comparison to the amicrofilaraemic groups of endemic normals and chronic patients. However, treating microfilaraemic people with diethylcarbamazine enhanced the antibody levels by 10-fold. These results suggest that active infection suppresses the response induced by the isolated antigenic fraction which is elevated after clearance of microfilariae.

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