Articles written in Journal of Biosciences
Volume 37 Issue 6 December 2012 pp 1041-1059 Articles
Volume 38 Issue 4 November 2013 pp 805-814 Articles
Type 2 diabetes is an inevitably progressive disease, with irreversible 𝛽 cell failure. Glycogen synthase kinase and Glukokinase, two important enzymes with diverse biological actions in carbohydrate metabolism, are promising targets for developing novel antidiabetic drugs. A combinatorial structure-based molecular docking and pharmacophore modelling study was performed with the compounds of
Volume 41 Issue 3 September 2016 pp 407-417
Hyperglycaemia in diabetes is either caused by reduced availability of insulin (type 1 diabetes, T1D) or insulinresistance to the cells (type 2 diabetes, T2D). In recent years, the prevalence of T2D has increased to an alarmingproportion, encompassing 95% of the total diabetic burden, probably due to economy-driven changes in lifestyle.Recent epidemiological studies show comorbid depression, anxiety and related mental illness. To explore themolecular mechanisms underlying this comorbid conditions, we used Sprague–Dawley rats on high-fructose dietfor 8 weeks to induce prediabetic condition. Rats with this metabolic syndrome also showed hyper-anxiety when theywere subjected to anxiety-related behavioural assays. Rats were administered with resveratrol, an activator of sirtuins,and metformin, a standard antidiabetic drug, simultaneously with fructose. We observed that resveratrol was moreeffective in protecting from both the metabolic (prediabetic) and affective (anxiety) disorders than metformin.Molecular studies showed that recovery was associated with the upregulation of few nuclear sirtuins that actepigenetically – Sirt 1 and 7, which were significantly attenuated in the striatum of prediabetic rats. In conclusion,our study showed that hyper-anxiety associated with prediabetic condition is ameliorated by resveratrol throughmodulation of sirtuins, which is more or less similar to metformin.
Volume 45 All articles Published: 27 August 2020 Article ID 0106 Article
Subcellular localization prediction of the proteome is one of major goals of large-scale genome or proteomesequencing projects to define the gene functions that could be possible with the help of computationalmodeling techniques. Previously, different methods have been developed for this purpose using multi-labelclassification system and achieved a high level of accuracy. However, during the validation of our blind datasetof plant vacuole proteins, we observed that they have poor performance with accuracy value range from
~1.3% to 48.5%. The results showed that the previously developed methods are not very accurate for the plantvacuole protein prediction and thus emphasize the need to develop a more accurate and reliable algorithm. Inthis study, we have developed various compositions as well as PSSM-based models and achieved a highaccuracy than previously developed methods. We have shown that our best model achieved ~63% accuracyon blind dataset, which is far better than currently available tools. Furthermore, we have implemented our bestmodels in the form of GUI-based free software called ‘VacPred’ which is compatible with both Linux andWindow platform. This software is freely available for download at www.deepaklab.com/vacpred.
Volume 46 All articles Published: 15 April 2021 Article ID 0034 Review
Prenatal environment significantly influences mammalian fetal development and adverse in utero conditionshave life-long consequences for the offspring health. Research has revealed that a wide variety of prenatalstress factors lead to increased risk of vulnerability to neuropsychiatric disorders in the individuals. Multiplemediators are involved in stress transfer from mother to the developing fetus, with stress hormone cortisolbeing a chief player. Further, the developmental programming effects of prenatal stress have been observed inthe form of alterations in the offspring brain at different levels. This review covers stress transfer mediatorssuch as cortisol, serotonin, maternal cytokines, reactive oxygen species (ROS) and the maternal microbiota,and their role in fetal programming. Prenatal stress leads to alterations in the offspring brain at multiple levels,from molecular and cellular to structural. These alterations eventually result in lasting phenotypic alterationssuch as in the offspring behavior and cognition. Different brain alterations induced by prenatal stress such as inneural pruning processes, neural circuit formation, brain structural connectivity and epigenetic systems regulatingneural gene expression are under focus in the second part of the review. The latter constitutes a keymolecular mechanism involved in prenatal stress effects and has been discussed in more detail.
Volume 46, 2021
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