Articles written in Journal of Biosciences
Volume 43 Issue 1 March 2018 pp 75-83 Article
In the developing central nervous system, transcription factors play a crucial role in the regulation of cell fate.Previously we demonstrated that LHX2 is a critical regulator of the neuron-glia cell fate switch in the developingmouse hippocampus. Here, we test LHX2 target gene Pax6 for a role in this process. We report that Pax6 overexpressionis able to suppress the enhanced astrogliogenesis arising due to loss of functional LHX2. Furthermore, weshow that like Lhx2, Pax6 is also able to suppress induced astrogliogenesis caused by overexpression of progliogenicfactor Nfia. This demonstrates that overexpression of Pax6 can substitute for Lhx2 in the regulation of the neuronalversus glial cell fate in the developing hippocampus, and therefore, supports a role for PAX6 as a mediator of LHX2function in this process.