Oxidation experiments, at 500°C, of MoSi2 and MoSi2-based compounds such as Mo(Al,Si)2 and MoSi2+1 wt% C compacts have been carried out. These compacts were prepared byin situ synthesis and a compaction method, starting from the elemental powders. For comparison, commercial MoSi2 and Mo(Al,Si)2 infiltrated into SiC preform were also studied under similar conditions. It was found that the synthesized high density MoSi2 and Mo(Al,Si)2 infiltrated into SiC preform did not show any oxidation even after 100 h of heating in air. The colour of the polished surfaces of commercial MoSi2, Mo(Al,Si)2 and MoSi2+1 wt% C had changed. The SEM of Mo(Al,Si)2 showed open blisters with rods of MoO3 in them whereas MoSi2+1 wt% C surface had MoO3 rods but no blisters and the oxidation was superficial with no penetration into the compact. It is suggested that in compounds, the presence of small amounts of impurities is not as detrimental to pesting as presence of defects like open pores or cracks. Hence, high density of the compact is essential for the prevention of complete disintegration of the compact.