• S NARENDHRAN

      Articles written in Bulletin of Materials Science

    • Potentiating effect of ecofriendly synthesis of copper oxide nanoparticles using brown alga: antimicrobial and anticancer activities

      SRI VISHNU PRIYA RAMASWAMY S NARENDHRAN RAJESHWARI SIVARAJ

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      This study reports the in vitro antimicrobial and anticancer activities of biologically synthesized copper nanoparticles. The antimicrobial activity of green synthesized copper oxide nanoparticles was assessed by well diffusion method. The anticancer activity of brown algae-mediated copper oxide nanoparticles was determined by MTT assay against the cell line (MCF-7). Maximum activity was observed with Pseudomonas aeruginosa and Aspergillus niger. Effective growth inhibition of cells was observed to be more than 93% in antibacterial activity. Thus, the results of the present study indicates that biologically synthesized copper nanoparticles can be used for several diseases, however, it necessitates clinical studies to ascertain their potential as antimicrobial and anticancer agents.

    • Toxicity of ZnO nanoparticles on germinating Sesamum indicum (Co-1) and their antibacterial activity

      S NARENDHRAN P RAJIV RAJESHWARI SIVARAJ

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      A comparative study of chemically (ZnO) and biologically synthesized (nano-ZnO) nanoparticles were carried out to determine the effect on seed germination of $Sesamum indicum$ (Co-1) by soaking method. Nano-ZnO is synthesized using $Lantana aculeata$ aqueous extract. Chemical synthesis of ZnO nanoparticles by precipitate method and was characterized by ultraviolet–Visible spectroscopy (UV–Vis), Fourier transform infrared spectrometer(FT-IR), energy dispersive X-ray spectrometer (EDX), X-ray diffractometer (XRD), field emission scanning electron microscopy (FESEM) and high resolution transmission electron microscopy (HRTEM). Antibacterial activity against pathogens was determined using well diffusion method. All the characterization analysis revealed that ZnO and nano-ZnO nanoparticles were spherical in shape with an average particle size of $18 \pm 2$ and $12\pm 3$ nm, respectively.Antibacterial studies conclude that nano-ZnO NPs have maximum zone of inhibition which was observed in $Pseudomonas aeruginosa$ ($15.60 \pm 1.0$ mm) at 100 $\mu$g ml$^{−1}$ concentration when compared to other ZnO NPs. Phytomediate ZnO have no adverse effects on seed germination, root elongation on $S. indicum$. But chemically synthesized ZnO nanoparticles significantly decreased in germination of $S. indicum$-treated samples and no changes were observed in bulk ZnO. These results clearly indicate the benefits of using bio-fabricate ZnO nanoparticles, i.e., more efficient in germination of $S. indicum$ and can also act as antibacterial agent. It can be used as nanofertilizer in environmental aspect of agricultural development.

    • Antibacterial, antioxidant properties of Solanum trilobatum and sodium hydroxide-mediated magnesium oxide nanoparticles: a green chemistry approach

      S NARENDHRAN M MANIKANDAN P BABY SHAKILA

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      A comparative study of Solanum trilobatum-mediated magnesium oxide (St-MgO) nanoparticles (NPs) and sodium hydroxide-mediated MgO (Che-MgO) NPs are synthesized using magnesium nitrate precursor. The characterization analyses, such as ultraviolet–visible spectroscopy (UV–Vis), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), energy-dispersive X-ray diffraction (EDX), scanning electron microscopy (SEM) and particle-size analysis were carried out. To determine the antioxidant activity of MgO NPs by 2,2-diphenyl-1-picrylhydrazyl (DPPH) method and antibacterial activity against Escherichia coli (MTCC: 912), Bacillus subtilis (MTCC: 121) and Streptococcus pyogenes (MTCC: 1925), was performed by the well-diffusion method. The UV–Vis analysis of St-MgO, Che-MgO confirmed the formation of MgO NPs that have a broad absorption peak at 362 and 374 nm, respectively. IR spectrum of synthesized St-MgO and Che-MgO exhibits a high-intensity band at 440 and 460 cm$^{−1}$, respectively. XRD analysis indicates that synthesized St-MgO, Che-MgO were crystal in nature and EDX confirmed the composition of MgO-NPs. SEM analysis revealed that St-MgO and Che-MgO NPs were spherical in shape without aggregation. Particle-size analysis confirmed that the average particle sizes of St-MgO and Che-MgO NPs were 30 and 42 nm, respectively. DPPH assay of St-MgO NPs has higher absorbance value, which indicates the high antioxidant capacity compared with ascorbic acid. St-MgO NPs are effective against bacterial pathogens, such as E. coli ($16.66 \pm 0.66$), B. subtilis ($16.00 \pm 0.88$) and S. pyogenes ($13.66 \pm 2.08$) at 100 mg ml$^{−1}$ concentration when compared with Che-MgO and the control ($P$ < 0.001). Thus, the result suggested that safer use of biologically synthesized MgO NPs can act as effective antioxidant and antibacterial agents in the field of biomedicine.

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