• SUDIP MUKHERJEE

      Articles written in Bulletin of Materials Science

    • Amphiphilic cationic macromolecule potentiates tetracycline against multi-drug resistant Gram-negative bacteria

      SUDIP MUKHERJEE SREYAN GHOSH JAYANTA HALDAR

      More Details Abstract Fulltext PDF

      Drug resistance in Gram-negative bacteria is leading the public health towards a global crisis and is further compounded by the dearth in developing new antibiotics to treat these pathogens over the last five decades. Among thevarious proposed mechanisms of resistance development, exclusion of drug from bacterial cells by efflux pumps act as an efficient machinery expelling a broad range of antibiotics thereby lowering intracellular antibiotic concentration andrendering the available antibiotics obsolete. Among various classes of antibiotics, tetracyclines suffer resistance through efflux mechanism. Currently, resurrecting the obsolete antibiotic by using the non-antibiotic drugs/adjuvants has becomeone of the key successes to tackle the multi-drug resistant (MDR) Gram-negative bacterial infections. Herein, we report the sensitization of tetracycline with the help of a membrane active macromolecule, ACM-A$_{\rm Hex}$ against the resistant Gram-negative pathogens. ACM-A$_{\rm Hex}$ was found to exert its antibacterial action by depolarizing the membrane potential. Thereby increasing the accumulation of tetracycline in Gram-negative pathogens. The combination of the compound with tetracycline has demonstrated 4–128-fold potentiation in the antibacterial activity of the antibiotic. Overall, these in vitro studies have demonstrated immense potential of this combination to be further developed as therapeutic agents to treat Gram-negative bacterial infections.

  • Bulletin of Materials Science | News

    • Dr Shanti Swarup Bhatnagar for Science and Technology

      Posted on October 12, 2020

      Prof. Subi Jacob George — Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bengaluru
      Chemical Sciences 2020

      Prof. Surajit Dhara — School of Physics, University of Hyderabad, Hyderabad
      Physical Sciences 2020

    • Editorial Note on Continuous Article Publication

      Posted on July 25, 2019

      Click here for Editorial Note on CAP Mode

© 2021-2022 Indian Academy of Sciences, Bengaluru.