• SUBASH CHANDRA BOSE GOPINATH

      Articles written in Bulletin of Materials Science

    • Electrospun cellulose acetate-doped 3D-graphene nanofibre for enhanced transduction of ochratoxin A determination

      ADEL MOHAMMED AL-DHAHEBI SUBASH CHANDRA BOSE GOPINATH MOHAMED SHUAIB MOHAMED SAHEED MAZLI MUSTAPHA

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      Ochratoxin A (OTA) is a public health concern because of its carcinogenic, teratogenic and immunotoxic nature, thus sensitive and selective monitoring of this molecule in food samples is of great importance. Herein, we reportthe development of a highly sensitive and selective electrochemical aptasensor using electrospun cellulose acetate (CA)-doped three-dimensional (3D)-graphene for OTA determination. The free standing electrospun CA/3D-graphenesurface was functionalized with silane and glutaraldehyde functional groups to tether terminal linkers for immobilizing OTA aptamer using the layer-by-layer deposition method. The current–voltage measurements of the proposed aptasensor revealed a low detection limit of 156 fg ml$^{-1}$ and sensitivity at 0.3 nA with a linear detection range of 1 fg ml$^{-1}$ to 1 ng ml$^{-1}$. This aptasensor did not show an interference effect during the selectivity test in the presence of other mycotoxins. The excellent applicability of the developed aptasensor has been verified in paddy rice-spiked samples, showing great potential in fields of food safety. The improved performance of this aptasensor is attributed to the large surface area, interconnected and porous structures of the electrospun fibrous membrane as well as the synergetic effect between graphene and the CA polymeric nanofibres, which creates a suitable matrix for aptamer immobilization and OTA interactions. The proposed aptasensor exhibits excellent sensitivity, selectivity, and thus could be a promising strategy for efficient on-site detection of OTA in food safety control and environmental monitoring.

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