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P K KALEENA
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Volume 44 All articles Published: 6 May 2021 Article ID 0132
D ELUMALAI T Y SUMAN M HEMAVATHI C SWETHA R KAVITHA C ARULVASU P K KALEENA
Ganoderma lucidum (G. lucidum) is a medicinal mushroom, which is rich in flavonoids as well as polyphenols and contains triterpenes, ganoderic acid. Thus, this research examined the biosynthesis of gold nanoparticles(GNPs) usingG. lucidum fruit body and their cytotoxicity, cell morphology and apoptosis detection against HT-29 colon cancer cell line. The study results revealed the occurrence of GNPs, as evidenced by ultraviolet–visible spectroscopy(UV–vis spectroscopy; 520 nm). The X-ray diffraction results show that the synthesized Au-NPs are crystalline. According to field-emission scanning electron microscope, transmission electron microscopy and atomic force microscope,the synthesized GNPS exhibited shapes such as spherical, oval and irregular in shape and the size ranges in between 1 and 100 nm.G. lucidum biofabricated GNPs showed inhibited HT-29 colon cancer cell line with an efficacy IC$_{50}$ of 84.58 ${\mu}$g ml$^{–1}$. The results indicated that the apoptotic effects were increased on cells based on the dose-dependent concentration of GNPs.
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Bulletin of Materials Science
Volume 46, 2023
All articles
Continuous Article Publishing mode
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Bulletin of Materials Science | News
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Dr Shanti Swarup Bhatnagar for Science and Technology
Posted on October 12, 2020Prof. Subi Jacob George — Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bengaluru
Chemical Sciences 2020Prof. Surajit Dhara — School of Physics, University of Hyderabad, Hyderabad
Physical Sciences 2020 -
Editorial Note on Continuous Article Publication
Posted on July 25, 2019Click here for Editorial Note on CAP Mode
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