Articles written in Bulletin of Materials Science

• Heating ability and biocompatibility study of silica-coated magnetic nanoparticles as heating mediators for magnetic hyperthermia and magnetically triggered drug delivery systems

The aim of this study is to prepare core–shell La0.73Sr0.27MnO3 –silica nanoparticles and evaluating their heat generation ability under the safe alternating magnetic field (𝑓 = 100 kHz and 𝐻 = 10–20 kA m−1) for potential applications in magnetic fluid hyperthermia and magnetically triggered drug delivery systems. The magnetic cores of La0.73Sr0.27MnO3 with an average particle size of 54 nm were synthesized by the citrate–gel method. Then, the Stober method was applied to encapsulate nanoparticles with 5-nm-thick silica shell. The core–shell structure of nanoparticles was confirmed by X-ray diffraction, fourier transform infrared spectroscopy and transmission electron microscopy analyses. Cytotoxicity of bare and silica-coated nanoparticles was evaluated by methyl thiazol tetrazolium bromide assay with MCF-7 cell line. The results revealed that the both samples have negligible toxicity below 500 𝜇g ml−1 and silica coating can improve the biocompatibility of nanoparticle. In addition, calorimetric measurements were used to determine the heating efficiency of the core–shell nanostructures in aqueous medium. The results showed that the heat generated of the prepared sample could be safely controlled in the range of 40–60°C which is suitable for biomedical applications.

• Preparation of manganese-based perovskite nanoparticles using a reverse microemulsion method: biomedical applications

In this study, La$_{0.7}Sr$_{0.3}Mn$_{0.98}$Ti$_{0.02}$O$_{3}$ (LSMTO) nanoparticles with a perovskite structure and an average particle size of 23.5 nm were synthesized using a reverse microemulsion method. In this method, cetyltrimethylammonium bromide (CTAB) was used as a surfactant, 1-butanol as a co-surfactant, $n$-hexane as a continuous oil phase, and an aqueous solution containing metal cations or precipitating agent as a dispersed aqueousphase. The aqueous nanodroplets of microemulsions were used for the formation of perovskite precursor. The obtained precursor was then calcined at 700$^{\circ}$C for 4 h to convert the precursor to the perovskite phase. In addition, the heating ability of the LSMTO nanoparticles was evaluated under a safe alternating magnetic field used in magnetic hyperthermia therapy. The results showed the fast magneto-temperature response of the prepared samplewith sufficient heat loss at the therapeutic temperature range, indicating the LSMTO nanoparticles can be used as a self-regulated heating agent in the magnetic hyperthermia therapy.

• Bulletin of Materials Science

Volume 44, 2021
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Continuous Article Publishing mode

• Dr Shanti Swarup Bhatnagar for Science and Technology

Posted on October 12, 2020

Prof. Subi Jacob George — Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bengaluru
Chemical Sciences 2020