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MEHDI MOVAHEDI
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Volume 45 All articles Published: 25 April 2022 Article ID 0076
Casein release and characterization of electrospun nanofibres for cartilage tissue engineering
MEHDI MOVAHEDI AMIN ORASH MAHMOUD SALEHI FATEMEH POODINEH HAJIPOUR SINA ETEMAD
Cartilage regeneration/reconstruct is a noticeable challenge in cartilage tissue engineering. In this study, through electrospinning technique, poly(caprolactone) (PCL), gelatin (Gel) and casein (Cas) were used to fabricate electrospun scaffold for cartilage tissue engineering applications. The physicochemical properties of fabricated scaffolds were assessed by scanning electron microscopy (SEM), water contact angle (WCA), mechanical assessment, water uptake measurement and
in-vitro degradation assay. The cell/scaffold interactions were assessed through MTT assay and SEM observation. The obtained results showed the uniform and bead-free PCL/Gel/Cas fibres produced with a mean diameter of about 259.27 ± 56.33 nm, and 15.98 ± 2.14 lm pore size. The tensile assessment revealed that PCL/Gel fibres with 2 wt% Cas reached 9.8 ± 1.6 MPa. The MTT assay also showed that PCL/Gel fibres with 2 wt% Cas had proper cell viability and proliferation comparable with PCL/Gel scaffold. It can be concluded that the PCL/Gel/Cas nanofibrous scaffold can be a desirable candidate for cartilage tissue engineering.
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Bulletin of Materials Science
Volume 46, 2023
All articles
Continuous Article Publishing mode
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Bulletin of Materials Science | News
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Dr Shanti Swarup Bhatnagar for Science and Technology
Posted on October 12, 2020Prof. Subi Jacob George — Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bengaluru
Chemical Sciences 2020Prof. Surajit Dhara — School of Physics, University of Hyderabad, Hyderabad
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Posted on July 25, 2019Click here for Editorial Note on CAP Mode
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