• MANZARBANOU ASNAASHARIISFAHANI

      Articles written in Bulletin of Materials Science

    • In-situ synthesized carboxymethyl chitosan/poly(vinyl alcohol) bio-nanocomposite hydrogels containing nanoparticles with drug-delivery properties

      IMAN GHOLAMALI MANZARBANOU ASNAASHARIISFAHANI ESKANDAR ALIPOUR ABBAS AKHAVAN SEPAHI

      More Details Abstract Fulltext PDF

      A drug-delivery approach was developed through effective preparation of bio-nanocomposite hydrogels in situ with ZnO/CuO/Ag nanoparticles being formed within swollen carboxymethyl chitosan (CMCh)/poly(vinyl alcohol) (PVA) hydrogels. Different experimental techniques, including Fourier transform-infrared, X-ray diffraction (XRD), energy-dispersive X-ray (EDX) analysis, and scanning electron microscopy (SEM) were applied to study and compare the prepared hydrogels. XRD and EDX analyses confirmed the formation of nanoparticles in the hydrogel matrix, while SEM micrographs showed that ZnO, CuO and Ag nanoparticles ranged from 36.26 to 76.09 nm, 34.15–71.71 nm and 36.21–78.47 nm within the same matrix, respectively. According to the results, an increased number of nanoparticles resulted from increased ion concentration. At pH 2.1 and pH 7.4, the bio-nanocomposite hydrogels were investigated in terms of the swelling behaviour; in comparison with neat CMCh/PVA hydrogel, they showed a pH-sensitive swelling ratio. As an in-vitro drug release test, the bio-nanocomposite hydrogels were applied to sustained and controlled drugdelivery system that increased with the increase in nanoparticles content that could result in protracted release of the ibuprofen.

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