Articles written in Bulletin of Materials Science
Volume 5 Issue 2 June 1983 pp 97-101
The hazards encountered in the clinical use of medical devices and implants have been referred in this paper to emphasise the need for and relevance of carrying out appropriate toxicological investigations before such items are manufactured and marketed. Different formulations of polyvinyl chloride, low density polyethylene, high density polyethylene and polyester fabric were subjected to various tests to determine their biocompatibility/safety for their eventual use as components in a bubble oxygenator. The test methods together with the results obtained are described and discussed.
Volume 9 Issue 5 December 1987 pp 309-315
Soft tissue reaction to metals, ceramics and composites was investigated over a long period. Titanium, nitrided titanium, ruby, sapphire and carbon-carbon composite materials were used. Histological response was uniform for all materials despite their differing chemical and physical properties.
Volume 12 Issue 1 March 1989 pp 17-25
Smooth, perfectly spherical, highly hydrophilic microspheres have been prepared from crosslinked poly(methyl methacrylate) microspheres by alkaline hydrolysis in ethylene glycol at elevated temperatures. These microspheres absorb varying quantities of water depending upon the extent of hydrolysis. Subcutaneous implantation studies on rabbits demonstrated that the microspheres are biocompatible. Implantation studies in the renal arteries of dogs demonstrated the occlusion effect produced by the microspheres. Microspheres could be made radiopaque by the incorporation of barium sulphate. Potential uses envisaged for these microspheres in the biomedical area are that of artificial emboli for endovascular embolization and as microcarriers for the growth and propagation of anchorage dependent mammalian cells.
Volume 17 Issue 2 April 1994 pp 171-179
In this paper we describe the toxicological tests done on a machinable glassceramic, prepared at the Defence Metallurgical Research Laboratory. Tests show no toxicity and biocompatibility is inferred.
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